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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 3
1996 19
1997 28
1998 23
1999 16
2000 29
2001 20
2002 11
2003 19
2004 21
2005 19
2006 24
2007 18
2008 15
2009 22
2010 15
2011 20
2012 24
2013 34
2014 44
2015 48
2016 57
2017 35
2018 32
2019 46
2020 48
2021 51
2022 24
2023 25
2024 10

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723 results

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Page 1
The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis.
Kobayashi H, Gieniec KA, Lannagan TRM, Wang T, Asai N, Mizutani Y, Iida T, Ando R, Thomas EM, Sakai A, Suzuki N, Ichinose M, Wright JA, Vrbanac L, Ng JQ, Goyne J, Radford G, Lawrence MJ, Sammour T, Hayakawa Y, Klebe S, Shin AE, Asfaha S, Bettington ML, Rieder F, Arpaia N, Danino T, Butler LM, Burt AD, Leedham SJ, Rustgi AK, Mukherjee S, Takahashi M, Wang TC, Enomoto A, Woods SL, Worthley DL. Kobayashi H, et al. Gastroenterology. 2022 Mar;162(3):890-906. doi: 10.1053/j.gastro.2021.11.037. Epub 2021 Dec 6. Gastroenterology. 2022. PMID: 34883119 Free PMC article.
METHODS: To elucidate CAF origins, we used a colitis-associated CRC mouse model in 5 different fate-mapping mouse lines with 5-bromodeoxyuridine dosing. ...To examine the prognostic significance of the stromal target, CRC patient RNA sequencing data and tissue micro …
METHODS: To elucidate CAF origins, we used a colitis-associated CRC mouse model in 5 different fate-mapping mouse lines with 5 …
CB(1)R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance.
Drori A, Gammal A, Azar S, Hinden L, Hadar R, Wesley D, Nemirovski A, Szanda G, Salton M, Tirosh B, Tam J. Drori A, et al. Elife. 2020 Nov 19;9:e60771. doi: 10.7554/eLife.60771. Elife. 2020. PMID: 33210603 Free PMC article.
The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulates leptin bioavailability and bioactivity. ...This caused mice to have higher levels of sOb-R circulating in their bloodstream. ...
The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulates leptin bioavailability and bioactivity …
Mouse placental cells secrete soluble leptin receptor (sOB-R): cAMP inhibits sOB-R production.
Yamaguchi M, Murakami T, Yasui Y, Otani S, Kawai M, Kishi K, Kurachi H, Shima K, Aono T, Murata Y. Yamaguchi M, et al. Biochem Biophys Res Commun. 1998 Nov 18;252(2):363-7. doi: 10.1006/bbrc.1998.9636. Biochem Biophys Res Commun. 1998. PMID: 9826535
The aims of this study were to identify whether mouse placenta secretes soluble OB-R (sOB-R) and to find the regulating factor of OB-R expression. ...Addition of leptin to the medium did not affect expression of OB-R mRNA. However, 8-brom …
The aims of this study were to identify whether mouse placenta secretes soluble OB-R (sOB-R) and to find the regulating …
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA. Chaurasia B, et al. Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4. Science. 2019. PMID: 31273070 Free PMC article.
Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart disease. By genetically engineering mice, we deleted the enzyme dihydroceramide desaturase 1 (DES1), which normally inserts a conserved double bond into the backbone of ceramides …
Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart disease. By genetically engineering mice …
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S. Patel S, et al. Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10. Cell Metab. 2019. PMID: 30639358 Free PMC article.
Circulating GDF15 levels manifest very modest changes in response to moderate caloric surpluses or deficits in mice or humans, differentiating it from classical intestinally derived satiety hormones and leptin. However, GDF15 levels do increase following sustained h …
Circulating GDF15 levels manifest very modest changes in response to moderate caloric surpluses or deficits in mice or humans, differ …
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.
Jouffe C, Weger BD, Martin E, Atger F, Weger M, Gobet C, Ramnath D, Charpagne A, Morin-Rivron D, Powell EE, Sweet MJ, Masoodi M, Uhlenhaut NH, Gachon F. Jouffe C, et al. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2200083119. doi: 10.1073/pnas.2200083119. Epub 2022 Mar 1. Proc Natl Acad Sci U S A. 2022. PMID: 35238641 Free PMC article.
SignificanceWhile increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 diabetes, and nonalcoholic fatty liver diseases (NAFLD), the involved mechanisms are still poorly described. Here, we show that, in both huma …
SignificanceWhile increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 d …
Leptin and obesity.
de Luis DA, Perez Castrillón JL, Dueñas A. de Luis DA, et al. Minerva Med. 2009 Jun;100(3):229-36. Epub 2008 Apr 4. Minerva Med. 2009. PMID: 19182739 Review.
The leptin receptor (OB-R) is a large membrane spanning protein that belongs to the gp 130 family of cytokine class I receptors. ...In conclusion, despite the great advances in our knowledge of leptin physiology, many areas of investigation remain. Future res …
The leptin receptor (OB-R) is a large membrane spanning protein that belongs to the gp 130 family of cytokine class I receptor …
B219/OB-R 5'-UTR and leptin receptor gene-related protein gene expression in mouse brain and placenta: tissue-specific leptin receptor promoter activity.
Mercer JG, Moar KM, Hoggard N, Strosberg AD, Froguel P, Bailleul B. Mercer JG, et al. J Neuroendocrinol. 2000 Jul;12(7):649-55. doi: 10.1046/j.1365-2826.2000.00501.x. J Neuroendocrinol. 2000. PMID: 10849209
The B219/OB-R promoter transcribes only OB-R transcripts, whereas the OB-R/GRP promoter initiates transcription of both OB-R and another protein of unknown function, called the leptin receptor gene-related protein (OB-RGRP). ...B219/OB-R …
The B219/OB-R promoter transcribes only OB-R transcripts, whereas the OB-R/GRP promoter initiates transcription of both …
Obesity and thinness: insights from genetics.
Farooqi S. Farooqi S. Philos Trans R Soc Lond B Biol Sci. 2023 Oct 23;378(1888):20220205. doi: 10.1098/rstb.2022.0205. Epub 2023 Sep 4. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 37661743 Free PMC article. Review.
Genetic disruption of key molecular components of the hypothalamic leptin-melanocortin pathway causes severe obesity in mice and humans. Physiological studies in people who carry these mutations have shown that the adipose tissue-derived hormone leptin primar …
Genetic disruption of key molecular components of the hypothalamic leptin-melanocortin pathway causes severe obesity in mice a …
Leptin/OB-R signaling is elevated in mice with Sjogren's syndrome and is implicated in disease pathogenesis.
Xu T, Xie W, Ma Y, Zhou S, Zhang L, Chen J, Cai M, Sun R, Zhang P, Yu S, Xu Z, Jiang W, Wu M. Xu T, et al. Biochem Biophys Res Commun. 2017 Jan 22;482(4):835-842. doi: 10.1016/j.bbrc.2016.11.121. Epub 2016 Nov 23. Biochem Biophys Res Commun. 2017. PMID: 27889607
In this study, we found the expression of leptin and its receptor OB-R in mouse models of SjS are elevated both locally and systemically during SjS progression. ...In conclusion, Leptin/OB-R signaling may be pathogenically involved in SjS and ma …
In this study, we found the expression of leptin and its receptor OB-R in mouse models of SjS are elevated both locally …
723 results